Pharmaceutical Contract Research

Analytical method development

We perform method development and validation for LC-MS/MS, GC-MS/MS, GC-MS, and HPLC-UV.

PK/PD studies

We provide full analytical support for pre-clinical PK/PD studies:

• Small molecule PK/PD studies by LC-MS/MS
• PK/PD analysis of metals by ICP-MS
• Analysis of plasma and many tissue types

ADME

• Metabolic stability (microsomes or hepatocytes)
• CYP Reaction Phenotyping
• CYP Inhibition
• CYP Induction
• Plasma protein binding studies
• Drug transporter substrate & inhibitor screening
• Caco-2 permeability
• Skin permeation

Impurity testing

• Toxic impurities
• Drug degradation products
• Residual solvents by GC-MS
• Heavy metals and minerals by ICP-MS

Antibody Drug Conjugate services

• Small-scale conjugation of linker payloads to antibodies in quantities suitable for in vitro and in vivo studies.
• Heterogeneous or site-specific conjugation.
• In vitro quantitation of payload loss/de-conjugation.
• Development of analytical methods for the determination of DAR.